Holding Hands: Using Peptide-Drug Conjugates (PDCs) for the Precise Treatment of Pulmonary Fibrosis
December 27 @ 10:00 am - 11:00 am
Free
Targeted therapy represents an emerging paradigm for the current biomedical research, since selective and precise delivery of drugs to diseased tissues may be a good strategy to improve the therapeutic efficiency of the drug/probe, to overcome drug resistance, to reduce the off-target effects and to early detect several diseased states. Among the different strategies, Peptide-Drug Conjugates (PDCs) – that is constructs composed by i) a peptidic/peptidomimetic targeting unit; ii) a linker that connects the targeting unit with the drug; iii) the active payload (drug) – which has emerged as new tools for targeted therapy.
In this context, Dr. Kelly and her colleagues synthesized a panel of PDCs aiming at the precise treatment of pulmonary fibrosis, where nintedanib – a potent kinase inhibitor approved for the treatment of idiopathic pulmonary fibrosis – and a peptidomimetic targeting αVβ6 integrin – which is a receptor overexpressed in fibrotic tissues – are connected by different linkers. Given the promising in vitro results of one synthesized PDC, the in vivo antifibrotic activity is currently under evaluation in mice models of pulmonary fibrosis.
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